NOS2 and Parkinson disease: In addition to inhibiting NF-κB activation and downregulating gene-related inflammation, chrysin also interacts with iNOS enzymes at a molecular level and COX-2 and decreases levels of arachidonic acid-induced prostaglandins, thromboxanes, and leukotrienes in the SN and ST of 6-OHDA- and MPTP-treated PD mice [151, 153].