Interestingly, authors then found that pinostrobin promoted phosphorylation of PI3K/AKT and ERK, and pharmacological inhibition of PI3K/AKT or ERK signaling diminished pinostrobin-induced Nrf2/ARE activation and neuroprotective actions against MPTP/MPP+-induced neurotoxicity in PD models [114]. Here, AKT1 is linked to Parkinson disease.