Previous research has examined the Nrf2 signaling-mediated antioxidant protection of neurons in numerous PD models, finding that Nrf2 directly regulates the activities of catalase (CAT), sulfiredoxin-1 (SRXN1), NAD(P) H:quinone oxidoreductase-1 (NQO1), superoxide dismutase 2 (SOD2), heme oxygenase-1 (HO-1), peroxiredoxins 3 and 5 (PRDX3 and PRDX5), and enzymes involved in GSH metabolism [101–103]. This evidence concerns the gene NFE2L2 and Parkinson disease.