Additionally, some studies have shown that Sirt6 attenuates the EMT process in some diseases, such as suppressing the TGF-β1/Smad3 pathway and c-Jun in an asthma model [40] or inactivating the TGF-β1/Smad2 pathway in bronchial epithelial cells [41]. The gene discussed is SMAD3; the disease is asthma.