Sirt6 (gene ID: 51548), also known as sirtuin 6 or SIR2L6, is a member of the sirtuin family of class III NAD+-dependent deacetylases, which affect the physiology of multiple cell types, tissues, and phenotypes associated with aging, cancer, metabolic disorders, and liver fibrosis [20–23]. This evidence concerns the gene SIRT6 and metabolic disease.