Sirt6 is a type of deacetylase that is important in the EMT process in different cells or diseases through different pathways, such as in promoting EMT by inhibiting KLF4 in non-small-cell lung cancer [37], by stimulating the autophagic degradation of E-cadherin in hepatocellular carcinoma [38], or by altering HIF-α activity in papillary thyroid cancer [39]. The gene discussed is KLF4; the disease is non-small cell lung carcinoma.