Such as MAPK, IL-1 signaling pathway, and STAT3 signaling pathway, which induce tumor cell proliferation, migration, invasion, and metastasis [29, 30], IL-20 can activate the STAT signaling pathway as an effective angiogenesis, chemotaxis, and proinflammatory cytokine, which is related to chronic inflammatory diseases such as psoriasis, rheumatoid arthritis, osteoarthritis, cancer, and liver fibrosis [31]. This evidence concerns the gene STAT3 and osteoarthritis.