For instance, miR-224-5p in papillary thyroid carcinoma targets EGR2 to promote cancer cell migration and invasion [18]; in breast cancer, miR-224-5p can suppress cancer cell autophagy [19], while in gastric cancer, miR-224-5p acts as an oncogene to facilitate cancer cell malignant behaviors [20]. This evidence concerns the gene EGR2 and cancer.