Multiple members of the sex determining region Y-box (sox) family (sox5, sox6, sox8a, and sox18) were shown to be significantly dysregulated in shox-deficient pectoral fins among other genes (nppa, nppc, cdkn1a, cdkn1ca, cyp26b1, and cy26c1), highlighting the important role of various gene family members in Shox-related growth disorders. Here, NPPC is linked to hereditary endocrine growth disease.