TAMs with M1 profile usually expressed MHC-II, CD68, CD80, and CD86 and had important antitumor and pro-inflammation function, while the M2 microphage in the tumor microenvironment could play a role in pro-tumor and anti-inflammation (Malfitano et al., 2020; Mantovani et al., 2021). Here, CD86 is linked to neoplasm.