A recent methylome and transcriptome study carried out in blood cells of patients affected by systemic sclerosis detected five DMGs that were hypo-methylated in heat challenged Nellore in the present study: inositol polyphosphate-5-phosphatase A (INPP5A), Spi-1 proto-oncogene (SPI1), transcription factor 3 (TCF3), in addition to F2RL3 and MAP3K1 (Zhu et al., 2018). Here, INPP5A is linked to systemic sclerosis.