We also found that the genes that are highly expressed after infection with A2-O in Cluster 8 and 9 include (1) defense-related genes encoding chitinase, β-1,3-glucanase, and serine protease inhibitor, (2) sesquiterpene synthase, (3) fatty acid desaturase 2 (FAD2), (4) ferulic acid 5-hydroxylase (F5H) which is involved in lignin biosynthesis, (5) berberine bridge enzyme (BBE)-like protein, which is involved in oxidation of cinnamyl alcohol (Figure 5B). The gene discussed is FADS2; the disease is infection.