Studies by Emamaullee et al. have reported that IL-25 administration in non-obese diabetic (NOD) mice with spontaneous T1D onset significantly reduces T cell infiltration in the pancreas and decreases serum autoantibodies with similar effects to anti-IL-17A administration, suggesting a protective role of IL-25 in the pathogenesis of T1D (78). This evidence concerns the gene IL17A and type 1 diabetes mellitus.