Also in lung cancer different studies have assessed the prognostic impact of TILs with different methodologies with regards to type of cell evaluated, compartment (stroma and/or intraepithelial cells), scoring (continuous vs semiquantitative), quantification (manual vs digital) and type of material (tissue microarrays vs whole sections); overall it appears that CD8+ cells are the most promising, regardless of the compartment analyzed, with some variation in the statistical trends (5). The gene discussed is CD8A; the disease is lung carcinoma.