VEGFA and systemic sclerosis: In SSc (Figure S8), there was a positive, moderate relationship between circulating VEGF level and pulmonary artery pressure (ES 0.62, 95% CI 0.37–0.87, P <0.0001; summary r = 0.55) and Medical Research Council dyspnea score (ES 0.65, 95% CI 0.08–1.22, P = 0.0246; summary r = 0.57).