Higher circulating VEGF levels were present in small (n ≤50) (SMD 1.58, 95% CI 1.10–2.05, P <0.0001) and large (n >50) (SMD 1.03, 95% CI 0.47–1.60, P <0.0001) studies on RA (Figure 3B-ii). This evidence concerns the gene VEGFA and rheumatoid arthritis.