In RA (Figure S7), there was a positive, weak correlation between circulating VEGF and disease activity (DAS-28; ES 0.33, 95% CI 0.22–0.44, P <0.0001, summary r = 0.32), ESR (ES 0.35, 95% CI 0.18–0.51, P <0.0001; summary r = 0.34) as well as C-reactive protein (CRP; ES 0.38, 95% CI 0.24–0.52, P <0.0001; summary r = 0.36). The gene discussed is VEGFA; the disease is rheumatoid arthritis.