Circulating VEGF levels were higher in active than in inactive Graves’ ophthalmopathy (GO) (SMD 0.80, 95% CI 0.29–1.30, P = 0.0019), without any heterogeneity (I2 = 0.00%, P = 0.7548) (Figure S5B). The gene discussed is VEGFA; the disease is Graves ophthalmopathy.