CD19 and neoplasm: To evaluate the long-term effect of NSAIDs on CD19.CAR-T cells, two different strategies for administration of celecoxib and aspirin were established based on an in vitro repetitive challenging assay, including a simultaneous treatment schedule that drugs and tumor cells were introduced to the system simultaneously (Figure 6), and a subsequent treatment schedule that drugs were introduced 24 hours after the addition of tumor cells (Figure 7).