used a bioinformatics approach of lesional psoriasis skin and atherosclerotic plaques, showed that IFN-γ and TNF-α are the dominant pro-inflammatory signals linking atherosclerosis and psoriasis, more importantly, both IFN-γ and TNF-α are increased in the serum of patients with moderate-to-severe psoriasis and their respective receptors in atherosclerotic plaques are increased. Here, TNF is linked to atherosclerosis.