CCN2 and Buschke-Ollendorff syndrome: Paired analysis revealed no significant difference in CTGF values at the different time points for stable and BOS patients (p=0.84 and p=0.92, respectively) (Figures 8A, B), whereas values had significantly increased in RAS patients at the moment of CLAD diagnosis compared to 1 year post-LTx (p=0.029) (Figure 8C and Supplementary Figure S3).