Whether or not HFD-induced intestinal tuft cell expression of Serpini1 may play a part in HFD-induced depression (33) or other neurodegenerative disorders like Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, and amyotrophic lateral sclerosis (34) will need further investigations. Here, SERPINI1 is linked to early-onset autosomal dominant Alzheimer disease.