In addition, platelet activating factor (PAF), which is known to be increased in dengue (31) and lipopolysaccharide (LPS), which has been reported to be increased as a result of loss of intestinal integrity (32), were both implicated as triggers of NET formation and may, therefore, also play a role in the pathogenesis of dengue (20, 33). Here, PCLAF is linked to dengue disease.