In addition, simian human immunodeficiency virus infected rhesus macaques who gained viral control when treated with combinatorial broadly neutralizing antibodies (bNAbs) became susceptible to infection when depleted of CD8+ T-cells, thus providing further evidence which supports the indispensable role of CD8+ T-cells in the control of viral replication (Nishimura et al., 2017). The gene discussed is CD8A; the disease is infection.