As for the explanation of the correlation between higher AMH and poor reproductive outcome in fresh cycle in PCOS women, firstly, AMH excess in GCs from PCO would be involved in the follicle excess of PCO (54–56) and the follicular arrest in anovulatory patients (33, 36), thus high AMH levels may result in the disturbed folliculogenesis of PCOS. The gene discussed is AMH; the disease is polycystic ovary syndrome.