Floating-Harbor syndrome, Cornelia de Lange syndrome, 3M syndrome, Meier-Gorlin syndrome, MOPD I, MOPD II, LIG 4 syndrome, XRCC4 syndrome, Severe growth restriction with distinctive facies, Resistance to IGF-1, Multisystem infantile onset autoimmune disease, Short stature with or without advanced bone age and early-onset osteoarthritis Brachydactyly type A, Short stature with nonspecific skeletal abnormalities. This evidence concerns the gene IGF1 and Cornelia de Lange syndrome.