Hypothalamic GnRH neurons act as a central regulator of LH synthesis because of abnormally increased GnRH pulse, LH pulse frequency, and amplitude in women with PCOS, which further enhance androgen synthesis in ovarian theca cell and promote hyperandrogenemia, ovarian dysfunction, and metabolic disorders in women with PCOS (3, 11). This evidence concerns the gene GNRH1 and Other metabolic disease.