After SG, metabolic disorders in PCOS rat including impaired glucose tolerance, decreased insulin sensitivity, and adiponectin levels are reversed, which is accompanied by decreased KISS1 gene expression in ARC, indicating that over-activated kisspeptin neurons can mediate metabolic regulation of central nervous system, then contribute to metabolic induced reproductive dysfunction in PCOS (55). The gene discussed is KISS1; the disease is polycystic ovary syndrome.