Furthermore, they explored the correlation among the identified MGS, metabolic parameters, SCFAs, and sex hormones and found that the colonization of Bifidobacterium lactis V9 promotes the growth of SCFA-producing microbiotas, thus promoting PYY and ghrelin secretion, which may act on hypothalamus GnRH neurons and mediate the beneficial effect of microbial derived SCFAs in alleviating neuroendocrine disorders of PCOS patients. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.