GNRH1 and polycystic ovary syndrome: On the other hand, prenatal androgen treated animal models are more often used for research investigating neuroendocrinal pathogenesis in PCOS, considering the high intrauterine androgen environment during pregnancy in women with PCOS, indicating that androgen and androgen activated GnRH synthesis may drive PCOS development since embryo, and this effect consistently exists till adulthood, leading to PCOS in offspring.