First, in the deficient iodine population, to make enough thyroid hormone to meet the needs of normal metabolism, follicular cells switch into autonomous hyperfunction, eventually leading to hyperthyroidism (26).Second, deficient iodine can lead to thyroid nodules, and thyroid antigens are released from the abnormal thyroid tissue in the nodules, which can lead to an increase in circulating thyroid autoimmune antibodies (27). This evidence concerns the gene TG and hyperthyroidism.