AR and Familial prostate cancer: TREM-1 is induced in macrophages by the androgen receptor signaling pathway in prostate cancer, and increases the motility and invasive capacity of prostate cancer cells (16). In recent years, many studies have suggested various strategies for regulating TREM-1 expression and activity to block the interaction between TREM-1 and its ligands to treat a number of diseases, including cancer (17, 18).