Seizure induced increase of vGlut1 labeled cells in vlPAG both in naïve rats (Pilo group) and in chronic epilepsy rats (SE+Pilo group) compared to control rats, but a significant lower increase in SE+Pilo group rats compared to Pilo group rats [Figure 6B, One-way ANOVA for comparison among groups, F(2, 18) = 9.907, p = 0.002; Pilo vs. control, p = 0.000; SE+Pilo vs. control, p < 0.046; SE+Pilo vs Pilo, p < 0.038]. The gene discussed is SLC17A7; the disease is Seizure.