LEP and alkaline phosphatase measurement: Further, patients using AP (both AP and APO/C/Q), had markedly higher leptin levels compared to patients not using AP (AP-), (p < 0.01 for both AP groups vs. AP-) and HC (p < 0.01 for both AP groups vs. HC), in analysis with further adjustment for AP treatment duration, and treatment with mood stabilizers (anticonvulsants and lithium).