Other research in European populations has also reported increased total PA to be significantly positively associated with metabolic health including fasting insulin, HOMA_IR, and CRP (Ekelund et al., 2007; Swindell et al., 2018), thus it is promising to also see metabolic benefits of total PA in other ethnic groups (i.e., Pacific) with higher metabolic disease risk. The gene discussed is CRP; the disease is metabolic disease.