ORMDL3 and asthma: ORMDL3-deficient mice are protected in a murine model of asthma with reduced AHR, lung eosinophils, allergen-specific serum IgE, and IL-6 in response to the fungus, Alternaria alternata, while overexpression of ORMDL3 enhanced AHR in this model (Loser et al., 2017).