The most commonly used animal models of PAH include: (1) PAH induced via vascular endothelial growth factor (VEGF) receptor blocker Sugen-5416 followed by exposure to hypoxia (SuHx), (2) Monocrotaline (MCT)-induced PAH, and (3) PAH induced via pulmonary artery banding (PAB) (Akazawa et al., 2020). This evidence concerns the gene VEGFA and pulmonary arterial hypertension.