ORAI1 and cancer: SOCE inhibition through STIM1 or ORAI1 knockdown inhibits the proliferation and metastasis of cancer cells, suggesting that SOCE may act as an oncogenic pathway (Yang et al., 2009; Chen et al., 2011; Yoshida et al., 2012; Motiani et al., 2013; Yang et al., 2013; Zhang et al., 2013; Kim et al., 2014; Umemura et al., 2014; Wang et al., 2015; Xu et al., 2015; Schmid et al., 2016; Xia et al., 2016; Goswamee et al., 2018; Wang Y. et al., 2018; Zang et al., 2019; Huang et al., 2020).