TRPC1 and malignant glioma: For example, TRPC1 was confirmed to play different roles in tumorigenesis, inhibition of TRPC1 by siRNA or SOCE inhibitors could suppress the proliferation and invasion of cancer cells including nasopharyngeal carcinoma, malignant glioma and non-small-cell lung carcinoma (Bomben and Sontheimer, 2010; He et al., 2012; Tajeddine and Gailly, 2012).