For example, the inhibition of SOCE by genetic deletion of ORAI1, STIM1, or STIM2 in murine CD4+ T cells impaired Th17 cell function, causing a decrease in the production of IL-17, which is believed to be proinflammatory factor important for tumor progression (Ma et al., 2010; Shaw et al., 2014; Mehrotra et al., 2019). Here, STIM1 is linked to neoplasm.