It was reported that LPS could regulate NLRP3/ASC/caspase-1 inflammasome complex to activate lung macrophage pyroptosis through p38 MAPK pathway in LPS-induced ALI model (Kovarova et al., 2012; Wu et al., 2015; Li et al., 2018; Zeng et al., 2019). Here, CASP1 is linked to acute respiratory distress syndrome.