We and others have demonstrated that gene expression, the level of endogenously produced ANG II, and the degree of subsequent hypertension can be precisely controlled in a dose and time-dependent manner (Peters et al., 2008; Erbanová et al., 2009; Peters et al., 2009; Husková et al., 2010; Husková et al., 2016; Honetschlägerová et al.,; Peters et al., 2012; Cunningham et al., 2013; Sporková et al., 2014; Jíchová et al.,; Sedláková et al.,). This evidence concerns the gene AGT and hypertensive disorder.