The reduced infarct size in the early phase of hypertension could be caused by heart adaptive responses, such as HIF-1 alpha induction, the action of heat-shock proteins, and induction of cardioprotective adipokines, mitochondria proliferation, etc. Recent reports indicate that Ang II-induced preconditioning exerts cardioprotective effects against I/R injury via AT2 receptors. Here, AGTR2 is linked to hypertensive disorder.