Recently, inbred transgenic rats with inducible hypertension [strain name, TGR (Cyp1a1–Ren-2)] have been generated using the cytochrome P-450 promoter, Cyp1a1, to regulate the expression of the mouse Ren-2 renin gene (Kantachuvesiri et al., 2001). This evidence concerns the gene REN and hypertensive disorder.