ACE and cardiovascular disorder: Several studies have shown that activation of the vasodilatory “ACE2/ANG 1–7/Mas receptor” axis, the one that usually counteracts the effects of vasoconstrictive “ACE/ANG II/AT1 receptor” axis and is therefore considered as beneficial, prevents and even attenuates the ANG II-induced damages observed in cardiovascular disease (Shi et al., 2010; Patel et al., 2016).