RUNX2 and thanatophoric dysplasia: Yao et al. found that after taking TFRD, chickens with Tibial dyschondroplasia (TD) recovered their walking ability earlier, repair and arrangement of chondrocytes were more regular, the vascular invasion of cartilage area was earlier, and the expression level of BMP-2 and Runx2 were higher (Yao et al., 2018).