The core targets were enriched in the regulation of mRNA processing, RNA polymerase, spindle assembly, hematopoietic stem cell differentiation, etc. The possible biological mechanisms involve the AGE–RAGE signaling pathway in diabetic complications, fluid shear stress, atherosclerosis, the MAPK signaling pathway, the PI3K–AKT signaling pathway, and HIF-1 signaling pathway; however, in vitro and in vivo studies are needed to verify these results. Here, PIK3CG is linked to atherosclerosis.