Previous studies indicated that some HLA alleles appeared to be a specific risk for AED-cADRs, such as HLA-B*15:02 for CBZ-induced SJS/TEN (Chung et al., 2004), whereas other HLA alleles showed common risk potential, such as HLA-A*24:02 for AED-SJS/TEN (Shi et al., 2017). This evidence concerns the gene HLA-A and toxic epidermal necrolysis.