Suppressed TGFβ/Smad3 signalling (COL2A1, HIF1a, Spry1, TPM1a downregulation) Qin et al. (2011) miR-29c in urine exosomes as a predictor of early renal fibrosis in lupus nephritis Sole et al. (2015). The gene discussed is SPRY1; the disease is renal fibrosis.