COL1A1 and Fuchs endothelial corneal dystrophy: Table 2 summarizes miR-29 expression in different fibrotic diseases. However, limited studies about miR-29 regulation were conducted in corneas. Downregulated miR-29 level was detected in clinical Fuchs’ corneal endothelial dystrophy (FECD) specimens while a wide range of miR-29 target genes was upregulated, suggesting a role of miR-29-related deposition of ECM in the pathogenesis of FECD (Matthaei et al., 2020). Overexpression of miR-29b suppressed ECM-related Col1A1, Col4A1, and laminin C1 expression in human corneal endothelial cells (Toyono et al., 2016).