Some pathways are closely related to metabolic syndrome, including advanced glycation end products (AGE)-receptor of AGE (RAGE) signaling pathway in diabetic complications (hsa04933), fluid shear stress and atherosclerosis (hsa05418), TNF signaling pathway (hsa04668), adipocytokine signaling pathway (hsa04920), insulin resistance (hsa04931) and non-alcoholic fatty liver disease (hsa04932). This evidence concerns the gene INS and atherosclerosis.