Compared to those in the ICG-l group, mice in the ICG-e had decreased β-catenin protein expression in the kidneys, less renal fibrosis, and lower protein levels of the β-catenin-downstream genes PAI-I and Snail1. Although protein expression of β-catenin and several fibrosis-related factors was downregulated in the ICG-l group, there was no obvious relief of renal tubulointerstitial fibrosis. This evidence concerns the gene SNAI1 and renal fibrosis.