Wnt1 canonical signaling activates fibroblasts directly or via interaction with TGF-β, and therefore has become a topic of considerable importance related to fibrosis in various renal diseases (Young et al., 1998; Duan et al., 2012; Li et al., 2016; Maarouf et al., 2016). This evidence concerns the gene TGFB1 and kidney disorder.