Not surprisingly, HYJJ down-regulated genes were enriched in inflammation-related pathways, such as cytokine-cytokine receptor interaction, TNF signaling pathway as well as IBD, NOD-like and Toll-like receptor signaling pathways (Figure 5F), fully corroborating the anti-inflammatory as well as the anti-cancer therapeutic role of HYJJ. Here, TNF is linked to inflammatory bowel disease.