GLP1R and heart failure: In a heart failure model induced by left coronary artery ligation (LCA), the high expression of miR-665 can reduce mitochondrial ATP enzymatic activity and damage cardiac function, whereas the inhibition of miR-655 can upregulate glucagon-like peptide 1 receptor (GLP1R) and cyclic adenosine monophosphate (cAMP) signaling to stabilize heart failure (Lin et al., 2019).