In patients with heart failure and TAC/MI- and Ang II-induced heart failure models, the high expression of miR-195 can downregulate SIRT3 activity, aggravating the excessive acetylation of pyruvate dehydrogenase complex (PDC) and ATP synthetase in patients—resulting in disordered mitochondrial energy metabolism (Zhang et al., 2018). Here, PDC is linked to heart failure.