SIRT3 and heart failure: In patients with heart failure and TAC/MI- and Ang II-induced heart failure models, the high expression of miR-195 can downregulate SIRT3 activity, aggravating the excessive acetylation of pyruvate dehydrogenase complex (PDC) and ATP synthetase in patients—resulting in disordered mitochondrial energy metabolism (Zhang et al., 2018).