On the other hand, existing studies have indicated that multiple drugs and genes such as melatonin, salidroside (SAL), estrogen, pyrogallol-phloroglucinol-6,6-bieckol (PPB) and fibroblast growth factor 21 (FGF21) decrease atherosclerosis plaque formation via inhibiting ECs pyroptosis in vivo and in vitro (Zhang et al., 2018; Oh et al., 2020; Xing et al., 2020; Zeng et al., 2020; Meng et al., 2021). Here, FGF21 is linked to atherosclerosis.