AKT1 and cancer: The PRC2 protein EZH2 interacts with Akt-1 in various cancers (Kleer et al., 2003; Piunti and Pasini, 2011; Chang and Hung, 2012; Yoo and Hennighausen, 2012; Gall Trošelj et al., 2016), and it mediates Akt activation via multiple mechanisms.