As shown in Supplementary Tables S1–S3 and Figure 4, the upregulated miRNAs in APTE (let-7i-5p, miR-320a, miR-320b-1, miR-320b-2, and miR-1291) and CTEPH (miR-320b-1) were significantly enriched in pathways of cancer, glioma, and PI3K-Akt signaling pathway, whereas the downregulated miRNAs in CTEPH (let-7i-5p, miR-320a, miR-320b-2, and miR-1291) and IPAH (miR-320a and miR-1291) were mainly enriched in pathways of cancer and apelin signaling pathway. The gene discussed is AKT1; the disease is central nervous system cancer.