EGFR and neoplasm: The EGFR has been confirmed to be closely related to tumor growth, progression, metastasis, and the poor prognosis of cancer patients, prompting extensive studies on the EGFR signaling pathway (Bishayee, 2000; Bridges, 2001; Ogiso et al., 2002; Hirsch et al., 2003; Bazley and Gullick, 2005; Allam et al., 2020; Han et al., 2020).