Given that genetic ablation of p38 in adipose tissues facilitated WAT browning upon cold stress and prevented diet-induced obesity (Zhang S. et al., 2018) and Sal A inhibited p38 MAPK signal pathway in variety of cells (Zhang et al., 2017; Zhang H. F. et al., 2018; Feng et al., 2020), we subsequently analyzed the possibility of p38-mediated UCP-1 induction in Sal A-treated adipocytes. This evidence concerns the gene UCP1 and obesity due to melanocortin 4 receptor deficiency.