Recently, Zhang and colleagues reported that Saporin, a strong cytotoxic compound, can significantly slow the growth of parental cancer cells and resistant ATP-binding cassette (ABC) transporter subfamily B member 1 (ABCB1)- and ABC transporter subfamily G member 2 (ABCG2)-overexpression cells when it has been encapsulated in lipid-based nanoparticles (Zhang et al., 2020). The gene discussed is ABCG2; the disease is cancer.