Thus, it is likely that we found the exposure of DOX-PMs-NPMBP markedly downregulated the expressions of cyclin D and cyclin E. Moreover, Hüllein J et al previously demonstrated the key role for tumor suppressor p53 in Burkitt lymphoma (BL) and identified MDM4 as a therapeutic target in various cancers. This evidence concerns the gene TP53 and Burkitt lymphoma.