TMPRSS2 and severe acute respiratory syndrome: TMPRSS2, human airway trypsin-like protease (HAT), TM protease, serine 13, serine protease DESC1, furin, factor Xa, and endosomal cathepsin L/B can cleave the SARS-CoV S-protein, facilitating SARS-CoV infection (Heurich et al., 2014).