Finally, we summarized the quality of ORR, DCR, QOL, myelosuppression, neutropenia, thrombocytopenia, gastrointestinal toxicity, hepatorenal toxicity, neurotoxicity, CD3+ T cells, CD3+ CD4+ T cells, and CD4+/CD8+ T cell ratios as “moderate” and other indicators as “low to very low” (Table 5). This evidence concerns the gene CD8A and neutropenia.