By contrast, prediction of AD was possible by the use of sprouty RTK signaling antagonist 2(SPRY2), vaccinia related kinase 3(VRK3), fibroblast growth factor 12 (FGF12), UDP-N-acetylglucosamine pyrophosphorylase 1(UAP1), and regulatory factor X3 (RFX3). The gene discussed is VRK3; the disease is Alzheimer disease.