MAPT and Alzheimer disease: Longitudinal data suggest greater cognitive decline and hippocampal atrophy rates in women after diagnosis of mild cognitive impairment (MCI) or AD (Hua et al., 2010; Holland et al., 2013; Lin et al., 2015; Gamberger et al., 2017), even though few differences have been reported to date in biomarkers of AD, such as accumulation of amyloid-β and tau proteins (Ferretti et al., 2018).