APOE and Alzheimer disease: APOE ε4-associated risk of AD was similar between males and females, with ORs of 3.85 (95% CI: 3.40–4.37) for AD in males and 4.10 (95% CI: 3.71–4.52) in females with one ε4 allele, and ORs of 13.24 (95% CI: 9.69–18.26) and 11.59 (95% CI: 9.19–14.76) in males and females with two ε4 alleles compared to non-carriers.