Previous studies revealed multiple variants with significant sex-by-genotype interactions in AD (Dumitrescu et al., 2019; Gamache et al., 2020), and genome-wide association studies (GWAS) have identified many AD susceptibility loci in addition to APOE (Harold et al., 2009; Lambert et al., 2009; Seshadri et al., 2010; Hollingworth et al., 2011; Naj et al., 2011; Jansen et al., 2019; Kunkle et al., 2019). The gene discussed is APOE; the disease is Alzheimer disease.