Among these plasma cytokines, plasma levels of IL-2 showed satisfactory discriminatory potential to identify cognitive decline in the aMCI group, and the AUC values were slightly increased when combining plasma levels of IL-2 with plasma levels of Aβ and tau biomarkers; however, in the AD group, all the investigated plasma cytokines did not reach significance for identifying cognitive decline. Here, MAPT is linked to Alzheimer disease.