In the continuity of these studies, our objective was to determine the respective contribution of modifiable risk/protective factors (allostatic load and cognitive reserve) on specific cognitive domains (episodic memory, executive functions, and attention), taking into account non-modifiable factors (sex, age, and APOE status) and brain AD-related biomarker level (Aβ and tau) in a healthy late-middle-aged population with a negative status for AD pathology. Here, MAPT is linked to Alzheimer disease.